Erythromycin lacks colon prokinetic effect in children with functional gastrointestinal disorders: a retrospective study

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Erythromycin lacks colon prokinetic effect in children with functional gastrointestinal disorders: a retrospective study

BACKGROUND Motilin, a peptide hormone has a direct excitatory effect on circular smooth muscle strips derived from the human colon. Reduced plasma motilin concentration has been reported in adults with chronic constipation. Erythromycin, a non-peptide motilin receptor agonist, induces phase 3 of the migrating motor complex (MMC) in the antro-duodenum and also reduces oro-cecal transit time. A p...

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Author's response to reviews Title: Erythromycin Lacks Colon Prokinetic Effect in Children with Functional Gastrointestinal Disorders, A Retrospective Study Authors:

Please ensure that the Abstract is present in the manuscript and matches exactly what is in the submission system. (Abstract Abstracts must be structured into Background, Methods, Results, Conclusions. Please remember to also update the Abstract details on the submission page.) Updated Title Please use sentence case in the title, both in the manuscript file and the submission system i.e. remove...

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Treatment of Functional Gastrointestinal Disorders in Children and Future Challenges

Functional gastrointestinal disorders (FGIDs) are a common problem in children. These disorders in children are classified into the following categories according to the ROME III classification: Functional Dyspepsia, Irritable bowel syndrome (IBS), Abdominal Migraines, Childhood Functional abdominal pain (FAP), Childhood functional abdominal pain syndrome and functional constipation. FGIDs are ...

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Role of Probiotics and Prebiotics in Functional Gastrointestinal Disorders in Children

Introduction: Functional gastrointestinal disorders (FGID) are non-fatal, unknown etiology disorders with absence of a structural or biochemical explanation and accounting for up to 50% of gastroenterology referrals. Infant regurgitation, rumination and cyclic vomiting constitute the vomiting disorders. Abdominal pain disorders are classified as: functional dyspepsia, irritable bowel syndrome (...

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Antidepressants for functional gastrointestinal disorders in children.

QUESTION Functional gastrointestinal disorders (FGIDs) are complex conditions I see in some of my pediatric patients. The indications for antidepressants such as selective serotonin reuptake inhibitors (SSRIs) do not include treatment of FGIDs; however, some children are prescribed SSRIs for this condition. Are antidepressants effective and safe to use for treating FGIDs in children and adolesc...

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ژورنال

عنوان ژورنال: BMC Gastroenterology

سال: 2008

ISSN: 1471-230X

DOI: 10.1186/1471-230x-8-38